Microbiology Contract Research Organization - CRO

Bacteriology Platform Team
SANOFI

Cutting-edge expertise, rigor, and a collaborative spirit: with Smaltis, we have found a trusted partner for outsourcing the production of specific bacterial preparations. Reliable results, time savings, and peace of mind guaranteed.

Caroline GEBUS
Microbiology Quality Control
OM Pharma

We use Escherichia coli strains to manufacture our Uro-Vaxom® product for the prevention of recurrent lower urinary tract infections and co-treatment of acute urinary tract infections and, in accordance with regulatory requirements, we must demonstrate the stability of our strains. We therefore asked Smaltis to develop a tailor-made quality control method. In addition to their ability to listen to customer needs and propose new ideas, the Smaltis team has also distinguished itself by the quality and accuracy of its analysis reports. At present, the partnership established with Smaltis is a real asset for OM Pharma.

Vincent THOMAS
R&D Innovation Director,
LALLEMAND HEALTH SOLUTIONS

As part of our R&D projects to develop innovative new products, we collaborated with the specialist laboratory Smaltis, to support certain stages requiring specific microbiology expertise. The Smaltis team became fully involved in our projects, and together we were able to design the manipulations in line with our objectives and the scientific data in the literature. The strong partnership approach demonstrated by this research provider enabled us to obtain qualitative data in line with our objectives, and to be able to count on a team committed to working with us.

Jérôme SCHMEISSER
Biology Lab Manager
DSM-FIRMENICH

In the context of our developments in animal health dietary supplements, we turned to SMALTIS to assess the impact of our products on the expression of genes of interest in different tissues. The molecular biology expertise of SMALTIS allows us to rely on this laboratory, whose qualitative results provide us with robust and reliable data. We also benefit from constructive exchanges with their teams to progress together throughout the project. SMALTIS thus constitutes a true extension of our R&D department, allowing us to focus on our own expertise while relying on this partner with whom we will continue to collaborate.

Delphine GALLAND
Head of Preclinical Clinical Studies
VETOQUINOL

For the past 10 years, we have regularly turned to Smaltis for their services and expertise in microbiology, cellular biology, and molecular biology. The entrusted work focused on evaluating the efficacy and safety of various products related to infectious diseases. The smoothness of our interactions, the responsiveness of the entire team, and their adaptation to our regulatory requirements have allowed us to advance our research projects optimally. The trust we have placed in Smaltis over these 10 years has led us to include this provider among our preferred contacts.

Clara LEANDRO
Head of Infection
TECHNOPHAGE

The advancement of Technophage's therapeutic pipeline products has received crucial support from SMALTIS in the scope of genetic modification of bacterial strains. Throughout this collaborative effort, the SMALTIS scientific team has demonstrated remarkable commitment to resolving various technical challenges, successfully aligning with our objective of acquiring a set of strains for our internal utilization, all within the stipulated timeline.

Pascal MERTENS
R&D Director
CORIS BIOCONCEPT

As part of the development of rapid in vitro diagnostic (IVD) tools for detecting infectious pathologies in humans, we needed to evaluate the performance of new tests dedicated to the detection of bacterial antibiotic resistance mechanisms. We approached Smaltis, a company specializing in microbiology and molecular biology, and found them ideally suited to our needs. Smaltis made its expertise available to assess the efficacy and robustness of our tests on clinical strains with very specific antibiotic resistance profiles, compared with a molecular biology method. The results confirmed the sensitivity, specificity and accuracy of our test, and enabled us to meet regulatory requirements. For us, the Smaltis laboratory is an expert player on whom we can rely to support our developments and obtain the data we need to bring our tools to market.

Thomas GLOUDEN
PCR Development Expert
UNISENSOR

As part of the development of a simple, rapid molecular test for the detection of certain pathogenic micro-organisms in milk, we needed to work with a company with expertise in microbiology. We were looking for a qualified and experienced laboratory to prepare calibrated microbial suspensions and purified genetic material from different bacterial species. By identifying Smaltis, we were able to fully achieve our objectives thanks to the expertise of their team. We now regularly rely on this trusted partner for our recurring needs.

Igor MIERAU
Director of Genetic Engineering and Manufacturing
AUREALIS THERAPEUTICS

Aurealis Therapeutics develops multi-target, scalable low COGS cell & gene therapies for unmet medical needs. As part of this effort, we needed to identify a laboratory to support specific research studies and meet regulatory objectives. We identified Smaltis, CRO expert in microbiology and molecular biology, able to answer our needs such as assessing the antimicrobial properties of some of our bacterial strains. We also exchanged about other protocols that could be put in place for our projects of strain characterization or clinical samples analysis. Smaltis is really a true partner for us, with which we can exchange about different purposes and collaborate to identify the best tests to be developed. We are happy to work with this passioned, reactive and flexible team!

Nicolas CHABERT
Chief Technical Officer
BIOINTRANT

As part of the development of our microbial biostimulants, and to ensure the health and safety of users of our products, we needed to evaluate the cytotoxicity of bacterial strains against a cell line. In this context, we turned to Smaltis to meet our needs. Their attentiveness and rigor in setting up the experimental conditions to perfectly match the expectations of the project, as well as the regular exchanges we benefited from, totally satisfied us. The analyses carried out met our strictest expectations in terms of safety of use, and provided us with reliable, interpretable results.

Nicolas COULIN
Laboratory Manager
SOLICAZ

Solicaz develops natural bacterial biostimulation solutions to meet the challenges of agro-ecological transition and climate change. These PGPG (Plant Growth Promoting Rhizobacteria) bacteria provide benefits for improving plant growth and resistance. In order to exploit their full potential, we needed to call on a molecular biology expert to robustly determine the identity of a pool of selected strains. We identified Smaltis, who fully met our expectations by providing comprehensive expertise. The laboratory proved to be a true partner of choice, with whom we worked jointly to identify and test the method best suited to our needs. Their flexibility and commitment ensure that we have reliable results, and despite the geographical distance that separates us, our various subsidiaries will continue to work with Smaltis.

Sandrine CLAUS
Founder & CEO
STARFISH BIOSCIENCE

I contacted Smaltis to urgently retrieve and secure a particularly valuable strain collection derived from our soil ecology research and essential to a high-stakes R&D project. Their responsiveness was decisive: within a few days, everything was organized, documented, and fully taken care of — a prerequisite for preserving the integrity and scientific value of these isolates. Beyond secure storage, collaborating with the Smaltis team allows me to continue the planned work on this collection directly at their facilities. This operational continuity greatly simplifies project management and prevents any interruption in our research workflow, especially for strains that are difficult to re-collect in the field. This partnership brings genuine peace of mind to my team. We know our strains are in good hands, kept in a controlled environment and monitored by an expert, reliable and responsive team. In a field where every sample matters, this level of care truly makes a difference.

Stéphane KROEMER
Preclinical and Clinical trials officer
DÔMES PHARMA

In the context of our animal health activities, we needed a partner capable of retrieving, centralizing, and securing our own strain collections as well as those provided by European collaborators. Smaltis quickly addressed this need by implementing a comprehensive and reliable storage solution. Their ability to manage different types of collections streamlines our logistics and ensures the rigorous traceability we rely on. Beyond storage, being able to draw on their expertise for strain identification and characterization enables us to confidently anticipate the next steps of our projects. This collaboration strengthens our operational efficiency while safeguarding strategic biological resources for our programs. We know our strains are managed with a high level of scientific rigor and a truly valuable sense of service.

Sophie MAC-MARY
CEO
SKINEXIGENCE

Smaltis is a laboratory that set up in the same building as our company, Skinexigence, from its inception. The proximity of our offices and the identification of a very interesting collaboration opportunity allowed us to quickly initiate a partnership to meet the growing demand from our clients for studies on the skin microbiota of volunteers. Specialized in the evaluation of the effectiveness of dermo-cosmetic products, it was only natural that we turned to Smaltis to provide our clients with expertise in the study of skin flora. For these studies, Smaltis performs skin sampling on our volunteers, sample preparation, and metagenomic analyses. The development of a very rigorous and calibrated protocol enables them to access relevant and reliable information regarding the evolution or not of the skin microbiota of a subject, in relation to the clinical parameters we observe.

Nathalie ROUDIER
Science & Innovation Director
BIOPROX HEALTHCARE

In the context of the use of probiotic strains as dietary supplements, we needed to evaluate the inhibition potential of pathogenic strains. We identified Smaltis, with whom we were able to discuss the various possible models adapted to our needs. Smaltis was able to deploy and optimize a protocol to demonstrate the desired effects. The Smaltis team proved to be very attentive to our needs and was able to meet the challenges we faced in adapting to the constraints of the living world. We were also able to call on the company to determine the Minimum Inhibitory Concentration of probiotic strains, in line with EFSA recommendations. We will continue to call on the Smaltis team if we ever need to turn to a quality service provider specialized in microbiology and molecular biology.

Eric SAMARUT
Co-founder and Scientific Director
OSTA THERAPEUTICS

Smaltis is an important partner for us, with whom we have established a close and early relationship to support the development of our new anti-infective molecules. We sought their recognized expertise in the field of antimicrobials and antibiotic resistance to support our proof of concept of the efficacy of our compounds, using specific strains from their mutant collection. With the help of growth kinetics, determination of Minimal Inhibitory Concentrations, and precise construction of mutant strains, along with their insightful advice and regular constructive exchanges, we obtained solid and essential elements to secure our data and continue our project.

Olivier DHELLIN
Director of Pharmaceutical Development
NEOVACS

During our program to develop and industrialize the production of our Kinoïdes® vaccines, Smaltis has proven to be a partner of choice for optimizing one of our cytokine production systems. Its service consisted in optimizing the genetic heritage of the host bacterium by excising DNA from exogenous sequences. Very attentive and with a rare expertise in microbiology, the Smaltis team has always been benevolent and has never hesitated to guide us by providing sound advice. It is with pleasure that we will again call upon the services of Smaltis to help us in our next challenges.

Valérie CHAZALET & Emeline RICHARD
CERMAV

As a public laboratory, we were looking for a reliable solution to externalize a backup copy of our bacterial strains in order to ensure their long-term preservation. This backup covered several research areas, each working with isolates presenting different characteristics and requirements. Smaltis quickly understood our challenges and implemented a perfectly tailored support approach. The reception of the isolates, their incubation under conditions specific to each strain, followed by viability and purity controls, were carried out with great rigor. At the end of this process, storage at –80 °C provided us with maximum security and preservation fully aligned with our expectations. Having an external backup of our collections gives us real peace of mind and strengthens the resilience of our scientific projects. We now know that our strains are stored in a controlled environment, monitored by an expert team with a strong commitment to process quality.

Elise JACQUIN
Associate Professor in Cell Biology
Unité CTM, Inserm U1231, Université de Bourgogne

To test the impact of mutations identified in cancer patients, we needed to reproduce them in an expression plasmid in order to measure their effects in cell transfection models. So we turned to Smaltis and their expertise in genetic engineering. The team understood our needs perfectly, and was able to efficiently implement the directed mutagenesis strategy to obtain the desired plasmids, while guaranteeing their high quality. As a result, we were able to rapidly carry out test manipulations, which proved conclusive and enabled us to obtain the preliminary data needed to submit a major funding application. We were fully satisfied with the team's professionalism in managing this project, and with the regular and easy exchanges of information on the progress of the manipulations. We look forward to working with Smaltis again in the future.