Experts in genomic and transcriptomic studies from complex matrices
Aware of the numerous applications enabled by genomic and transcriptomic studies, as well as the manipulation of genetic material, Smaltis equipped itself with a molecular biology platform from its inception to support projects requiring expertise in genetic material handling, in various contexts.
With 15 years of experience in this field, Smaltis experts apply their knowledge to offer you routine analyses or tailor-made studies, from the design of operating procedures to data analysis, to help you make the most of your projects.
Analyze your products and samples by entrusting them to molecular biologists
Smaltis works with all types of samples, from the simplest to the most complex, adapting protocols accordingly. Smaltis can source these samples as needed.
Your products or samples:
- Cellular products: microorganisms, eukaryotic cells
- Molecular products: RNA, DNA, cDNA, plasmids…
- Clinical samples: blood products, tissues/biopsies, skin or vaginal swabs, feces…
- Environmental samples: water, sludge, soil…
- Products from industrial processes
- Diagnostic kits or detection tools for research
- Equipment and/or reagents for use in molecular biology
Routine services and custom studies
To meet diverse needs
VALIDATION OF KITS & REAGENTS
PHARMACEUTICAL RAW MATERIAL CONTROL
Molecular characterization of complex samples
Assessment of the impact of products or processes on molecular targets of interest
External validation/comparison of molecular biology reagents/equipment/kits for research or diagnostic use
Quality control of pharmaceutical raw materials such as plasmids, recombinant proteins and microorganisms used in pharmaceutical bioprocesses
Total DNA extraction, high-throughput sequencing to identify microorganisms present and analyze microbial diversity
Complete design of the study protocol and analysis of transcript quantity by RT-qPCR of genes of interest after RNA extraction
Determination of the efficacy of diagnostic kits of resistant clinical strains or detection of pathologies related to mutations, by qPCR from DNA of strains or patients
PFGE analysis, development of targets for MLST, Multiplex PCR, control of restriction profiles, sequencing…
Our promise: adaptability and reliability to support your projects with confidence
With its comprehensive and versatile expertise in molecular biology, our teams have the capability to work with all types of samples, from the simplest to the most complex. Smaltis offers both routine analyses following standardized protocols and customized analyses with an upstream phase of biological material preparation. With agility, flexibility, and precision, Smaltis accompanies you from the design stage of operating procedures to the analysis of molecular biology data.
For every requirement, Smaltis responds by adapting the manipulation protocol to the context of your project and your objective. The operating procedure is established and optimized based on the products and samples to be evaluated, as well as the choice of reagents. This development stage is carried out with you, in a spirit of co-construction, to achieve the best results.
For specific projects requiring a particular technology, the Smaltis team seeks to identify and develop high-tech methods to meet the objective. For instance, Smaltis has adapted a method of RCA PCR to amplify and detect circular DNA molecules such as circular viral genomes or mitochondrial DNA present in very small quantities in complex samples.
Analyses and samples undergo rigorous quality control, ensuring the robustness of the results obtained. Our teams systematically verify the integrity of samples, the validity of the method, and implement various checkpoints throughout the protocol.
Interpreting molecular biology data requires expertise and rigorous analysis of the results, in line with the study’s objectives. The Smaltis team conducts a detailed and precise study to provide you with relevant, accurate, and easily exploitable data, allowing you to move forward with your project effortlessly.
It is essential for us to work with a strong partnership approach, both with our clients and our suppliers. Indeed, for certain projects, our researchers may turn to specialized service providers that Smaltis can rely on for the contribution of specific expertise. For example, we may engage qualified and specialized sequencing suppliers to obtain reliable results with a method adapted to the analyzed samples.
They trust us
Testimonials and references
Cell Biology Lab Manager,
DIACLONE SAS part of Medixbiochemica
Smaltis is a long-term partner with whom we have established a privileged relationship. We work in highly complementary domains and collaborate regularly to provide a comprehensive offering to our clients, utilizing microbiology and molecular biology services that we specifically require. We engage them for services such as sample contamination analysis, production of competent bacteria, and preparation of suspensions of inactivated strains for the development of new monoclonal antibodies. A true bond of trust has developed, facilitated by the geographical proximity of our respective locations and easy communication with their teams, whose flexibility, tenacity in problem-solving, and quality of work are crucial for us.
Jérôme SCHMEISSER and Christelle IACONIS
Biology lab manager
In the context of our developments in animal health dietary supplements, we turned to SMALTIS to assess the impact of our products on the expression of genes of interest in different tissues. The molecular biology expertise of SMALTIS allows us to rely on this laboratory, whose qualitative results provide us with robust and reliable data. We also benefit from constructive exchanges with their teams to progress together throughout the project. SMALTIS thus constitutes a true extension of our R&D department, allowing us to focus on our own expertise while relying on this partner with whom we will continue to collaborate.
Founder and President
Specialized in the production of cell banks from blood, for research and patient use, we needed to rely on a microbiology company to ensure the absence of contamination in our products from the start of our preparations. Established at the time in the premises of the EFS, it was only natural that we turned to Smaltis, located a few steps from our laboratories. Their work approach and the reliability of their results were exactly what we were looking for, and for several years now, we have entrusted them with all our microbiological analyses. The growth of our respective companies led us to look for new premises... and it is with pleasure that we took over the premises of Smaltis, who then moved into the building just across the street! It is important to have Smaltis in our network of reliable partners with common values, to contribute to the improvement of health!
As part of the development of rapid in vitro diagnostic (IVD) tools for detecting infectious pathologies in humans, we needed to evaluate the performance of new tests dedicated to the detection of bacterial antibiotic resistance mechanisms. We approached Smaltis, a company specializing in microbiology and molecular biology, and found them ideally suited to our needs. Smaltis made its expertise available to assess the efficacy and robustness of our tests on clinical strains with very specific antibiotic resistance profiles, compared with a molecular biology method. The results confirmed the sensitivity, specificity and accuracy of our test, and enabled us to meet regulatory requirements. For us, the Smaltis laboratory is an expert player on whom we can rely to support our developments and obtain the data we need to bring our tools to market.
News and articles
AMR Conference 8th edition
Smaltis is happy to participate to the 8th edition of AMR Conference in Basel from March 6th to 7th 2024, a platform for SMEs, start-ups, big pharma, academia, investors and public institutions to discuss strategies and specific challenges faced by the innovation ecosystem in bringing new antimicrobial treatments and diagnostics to the market.READ THE POST
The same… But better!
The year 2024 marks the 10th anniversary (already!) of the Smaltis adventure! 10 years of microbiology, 10 years of molecular biology, 10 years of passion, 10 years of twists and turns, 10 years of growth, 10 years of self-reflection, 10 years of continuous improvement, 10 years of scientific spirit, 10 years of ambition, 10 years of collaboration, 10 years of human relationships…
It was necessary to celebrate this milestone, and not just by blowing out the candles.READ THE POST
The Polepharma Microbiomics Days
Smaltis is delighted to have participated in and sponsored, for the fourth consecutive year, the Polepharma Microbiomics Days, held in Rouen on November 22 and 23, 2023.READ THE POST
The man who wanted to extend lifespan
Once upon a time, more than a century ago, Elie Metchnikoff hypothesized that health could be improved, and senility delayed by modulating the intestinal microbes thanks to bacteria present in yogurt. This zoologist and microbiologist was thus one of the first scientists to take an interest in gut microbiota and what we now call probiotics, the consumption of which he claimed helped to fight against aging.
This is the story of “the man who wanted to extend lifespan”.READ THE POST
All our sincere wishes
In this new year that begins, let’s take the time…
Let’s take the time to extend our best wishes to you, from the bottom of our hearts. It seems essential to us, during these periods conducive to gratitude, to prioritize human relationships as the most important aspect of our lives.READ THE POST