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Experts in exploring the health potential of microbiota

Convinced by the new therapeutic era represented by microbiota, Smaltis has been involved for over ten years in the study of roles played by microorganisms in health and well-being. With its innovative models and the acquisition of expertise in designing tailor-made experiments, Smaltis is committed to providing you with its expertise in the field, actively collaborating with you to accelerate the development of your prophylactic or therapeutic health products that target a microbiota.

Enhance the value of your products by entrusting them to a qualified laboratory

Whether your products are derived from microorganisms and/or act on a specific microbiota, optimize and streamline their development by entrusting them to our laboratories.

Smaltis actively supports the development of microorganisms and related products, such as:

  • Live Biotherapeutic Products (LBP)
  • Probiotics
  • Postbiotics
  • Synbiotics…


Our services also support projects based on other active compounds, which may include:

  • Prebiotics
  • Extracts
  • Drug candidates…

A global approach dedicated to your developments

From screening stages to clinical studies










Strain screening,
Collection of strategic and regulatory data,
Identification of optimizations

Search for health benefits,
Description of mechanisms of action,
Identification of biomarkers of interest for (pre)clinical or companion tests

Optimization of the bioproduction process,
Quality controls of products

Verification of the (pre)clinical impact of candidates,
Tracking biomarkers to generate supporting data,
Monitoring of strains


Functional and safety characterization of strains,
Genomic modification of strains

Study of flora modulation,
Study of membrane permeability

Optimization of culture conditions,
Stability study,
Strain inactivation & Controls

Analysis of clinical samples & Metagenomic studies,
Support for data analysis

Our promise: commitment and reliability to facilitate and accelerate your developments

The therapeutic potential revealed through the exploration of microbiota requires science and rigor, values on which Smaltis is uncompromising. The researchers at Smaltis accompany you with their expertise, dedicated equipment, and reliable partners to successfully execute your projects with the precision and flexibility unique to each study. From the development stages to data interpretation, we work hand in hand with your teams to achieve robust and clear results you can rely on.

From the design of manipulations to data interpretation, the project is carried out in partnership with your teams, ensuring complete transparency in terms of results and experiment progress. The goal is to find the best solution for your projects, applying the scientific rigor they require.

For each project, Smaltis commits to deploying all its efforts to finding solutions tailored to your challenges and that overcome the inherent obstacles in manipulating microorganisms. Perseverance pays off, a saying that we live up to!

Smaltis collaborates with experts to provide complementary solutions, addressing all your various needs. The team benefits, for example, from a strategic partnership with RD-Biotech, specialized in the biomanufacturing of plasmids and antibodies.

Smaltis is a member of networks working on microbiome-related themes, such as the Programming Committee of the Polepharma Microbiomics Days, to stay closely attuned to the developments and needs of this sector, the challenges you face, and the solutions to be provided.

Smaltis has the necessary equipment and tools for culturing even the most demanding microorganisms, be it bacteria, yeast, or molds. Smaltis has demonstrated its capabilities with a wide range of species and strains. The laboratory is equipped, among other things, with an anaerobic station that allows for precise regulation of growth atmospheres.

They trust us

Testimonials and references

Karine ROGET
Chief Scientific Officer

As part of our programs to harness microbiota to improve human health, we called on Smaltis to demonstrate the antimicrobial activity of our pharmaceutical product to combat vaginosis. Smaltis demonstrated great expertise and efficiency in setting up relevant protocols adapted to our objective, while coping with the complexities inherent in handling particular strains in equally complex environments. The energy deployed by the Smaltis team and their ability to adapt have confirmed our choice of this expert, on whom we can rely for our other projects.


As part of the development of our candidate EB8018 designed to block bacteria expressing virulence factor FimH (a key inducer of the inflammatory cascade of the intestine, particularly in patients with Crohn disease), we have successively called upon the services of SMALTIS. In the preclinical phase, they first quantified in vitro the adhesion and invasion capacities of a collection of strains isolated from patients on a model of intestinal cell infection and then evaluated the impact of our molecule on these strains. The quality of the work performed, the level of expertise of the team combined with the ability to listen and adapt, led us to include SMALTIS as a service provider in our Phase 1b clinical study. The team developed a customized procedure to isolate and dissociate bacteria called "adherent" and "invasive" in intestinal biopsies, and then demonstrated the action of our EB8018 compound on these strains. SMALTIS continues to support the development of EB8018 in a phase 2a clinical trial.

Head of Preclinical Research - Co-founder

As part of the Oncobax®-AK project and the development of Live Biotherapeutic Products to potentiate the efficacy of cancer immunotherapies, we called upon Smaltis' services to characterize one of our candidate bacterial strains. The objective was to provide a complete file to the regulatory authorities regarding the characteristics of the strain, before initiating clinical studies. The Smaltis team worked hard to develop the protocols and test conditions necessary to determine the specificities of the strain of interest. The rigor shown by Smaltis' researchers, the quality and detail of the data transmitted, as well as the scientific relevance of the various characterization tests, allowed us to meet the regulatory requirements and to initiate the clinical trials with confidence. We are delighted to have collaborated with Smaltis.

Caroline GEBUS
Bioprocess Scientist
OM Pharma

We use Escherichia coli strains to manufacture our Uro-Vaxom® product for the prevention of recurrent lower urinary tract infections and co-treatment of acute urinary tract infections and, in accordance with regulatory requirements, we must demonstrate the stability of our strains. We therefore asked SMALTIS to develop a tailor-made quality control method. In addition to their ability to listen to customer needs and propose new ideas, the SMALTIS team has also distinguished itself by the quality and accuracy of its analysis reports. At present, the partnership established with SMALTIS is a real asset for OM Pharma.

Chief Technical Officer

As part of the development of our microbial biostimulants, and to ensure the health and safety of users of our products, we needed to evaluate the cytotoxicity of bacterial strains against a cell line. In this context, we turned to Smaltis to meet our needs. Their attentiveness and rigor in setting up the experimental conditions to perfectly match the expectations of the project, as well as the regular exchanges we benefited from, totally satisfied us. The analyses carried out met our strictest expectations in terms of safety of use, and provided us with reliable, interpretable results.

Nathalie ROUDIER
Science & Innovation Director

In the context of the use of probiotic strains as dietary supplements, we needed to evaluate the inhibition potential of pathogenic strains. We identified Smaltis, with whom we were able to discuss the various possible models adapted to our needs. Smaltis was able to deploy and optimize a protocol to demonstrate the desired effects. The Smaltis team proved to be very attentive to our needs and was able to meet the challenges we faced in adapting to the constraints of the living world. We were also able to call on the company to determine the Minimum Inhibitory Concentration of probiotic strains, in line with EFSA recommendations. We will continue to call on the Smaltis team if we ever need to turn to a quality service provider specialized in microbiology and molecular biology.


Smaltis is a laboratory that set up in the same building as our company, Skinexigence, from its inception. The proximity of our offices and the identification of a very interesting collaboration opportunity allowed us to quickly initiate a partnership to meet the growing demand from our clients for studies on the skin microbiota of volunteers. Specialized in the evaluation of the effectiveness of dermo-cosmetic products, it was only natural that we turned to Smaltis to provide our clients with expertise in the study of skin flora. For these studies, Smaltis performs skin sampling on our volunteers, sample preparation, and metagenomic analyses. The development of a very rigorous and calibrated protocol enables them to access relevant and reliable information regarding the evolution or not of the skin microbiota of a subject, in relation to the clinical parameters we observe.

Nicolas COULIN
Laboratory Manager

Solicaz develops natural bacterial biostimulation solutions to meet the challenges of agro-ecological transition and climate change. These PGPG (Plant Growth Promoting Rhizobacteria) bacteria provide benefits for improving plant growth and resistance. In order to exploit their full potential, we needed to call on a molecular biology expert to robustly determine the identity of a pool of selected strains. We identified Smaltis, who fully met our expectations by providing comprehensive expertise. The laboratory proved to be a true partner of choice, with whom we worked jointly to identify and test the method best suited to our needs. Their flexibility and commitment ensure that we have reliable results, and despite the geographical distance that separates us, our various subsidiaries will continue to work with Smaltis.

Director of Genetic Engineering and Manufacturing

Aurealis Therapeutics develops multi-target, scalable low COGS cell & gene therapies for unmet medical needs. As part of this effort, we needed to identify a laboratory to support specific research studies and meet regulatory objectives. We identified Smaltis, CRO expert in microbiology and molecular biology, able to answer our needs such as assessing the antimicrobial properties of some of our bacterial strains. We also exchanged about other protocols that could be put in place for our projects of strain characterization or clinical samples analysis. Smaltis is really a true partner for us, with which we can exchange about different purposes and collaborate to identify the best tests to be developed. We are happy to work with this passioned, reactive and flexible team!

News and articles


Smaltis attends the 34th edition of the ECCMID international congress, renamed ESCMID Global, in Barcelona from April 27 to 30, 2024. This clinical microbiology and infectious diseases event is one of the largest and most important congresses in the field of infection, bringing together over 16,000 participants from all over the world to contribute to the dissemination of scientific knowledge.


Sanofi Vaccines R&D Day

Smaltis attends the Sanofi Vaccines R&D Day, organized by Sanofi in partnership with Lyonbiopôle, Enosis Santé and Polepharma!
This event aims to foster partnerships around 5 themes: antimicrobial approaches, therapeutic vaccines and antibodies, mucosal or skin delivery of vaccines, immunology, and antigen design. Quite a program!

Cédric Muller will be present at this event, which will take place on April 11, 2024, at 14 Espace Henry Vallée in Lyon.


Viruses at the service of humanity?

Once upon a time, the English bacteriologist Ernest Hankin demonstrated for the first time the presence of anti-bacterial entities in the waters of Indian rivers, putting humanity on the path to a promising anti-infectious therapy that is more relevant than ever.


Microbiota & Health Day 7th edition

Smaltis is delighted to be taking part in the 7th edition of Microbiota & Health Day, organized by Lyonbiopôle and Alliance Promotion Microbiote, on March 26, 2024 in Lyon. The aim of this day is to bring together academic, clinical and industrial players to discuss topical issues that are driving innovation in the field of microbiota and their impact on health.


AMR Conference 8th edition

Smaltis is happy to participate to the 8th edition of AMR Conference in Basel from March 6th to 7th 2024, a platform for SMEs, start-ups, big pharma, academia, investors and public institutions to discuss strategies and specific challenges faced by the innovation ecosystem in bringing new antimicrobial treatments and diagnostics to the market.


The same… But better!

The year 2024 marks the 10th anniversary (already!) of the Smaltis adventure! 10 years of microbiology, 10 years of molecular biology, 10 years of passion, 10 years of twists and turns, 10 years of growth, 10 years of self-reflection, 10 years of continuous improvement, 10 years of scientific spirit, 10 years of ambition, 10 years of collaboration, 10 years of human relationships…

It was necessary to celebrate this milestone, and not just by blowing out the candles.


The Polepharma Microbiomics Days

Smaltis is delighted to have participated in and sponsored, for the fourth consecutive year, the Polepharma Microbiomics Days, held in Rouen on November 22 and 23, 2023.


The man who wanted to extend lifespan

Once upon a time, more than a century ago, Elie Metchnikoff hypothesized that health could be improved, and senility delayed by modulating the intestinal microbes thanks to bacteria present in yogurt. This zoologist and microbiologist was thus one of the first scientists to take an interest in gut microbiota and what we now call probiotics, the consumption of which he claimed helped to fight against aging.

This is the story of “the man who wanted to extend lifespan”.


All our sincere wishes

In this new year that begins, let’s take the time…

Let’s take the time to extend our best wishes to you, from the bottom of our hearts. It seems essential to us, during these periods conducive to gratitude, to prioritize human relationships as the most important aspect of our lives.