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A winning team!

Specialists committed to your projects 


Co-founder and CEO of Smaltis

Cédric holds a PhD in life and health sciences from the Université de Franche-Comté, which he obtained for his work entitled: Characterization of mutants overproducing the MexXY/OprM active efflux system in Pseudomonas aeruginosa. His research was supervised by Professors Patrick Plésiat and Katy Jeannot, the latter now heading France’s National Reference Center for Antibiotic Resistance. Cédric thus acquired solid expertise in the field of antibiotic resistance, and was able to launch the creation of Smaltis with Sophie, in order to offer tailor-made microbiology services to healthcare companies.

His strengths: visionary, far-sighted and a go-getter!



Co-founder and Managing Director of Smaltis

Sophie holds a PhD in life and health sciences from the Université de Franche-Comté, which she obtained for her work entitled: Function and dysfunction of active efflux systems in clinical strains of Pseudomonas aeruginosa. Her research was supervised by Professor Patrick Plésiat. Under his guidance, Sophie acquired remarkable scientific rigor and knowledge of microbiology. This expertise, coupled with her desire to set up her own business, naturally led her to found Smaltis with Cédric to support the development of healthcare products.

Her strengths: persevering, optimistic and meticulous!



QHSE Manager

After graduating in Biotechnology Engineering from the Ecole Supérieure d’Ingénieur de Luminy in 2004, Marjorie acquired solid experience both abroad with Oxford BioMedica and in France with IATEC France. In 2009, she joined the CNR de la Résistance aux Antibiotiques team in Besançon as laboratory manager. She joined the Smaltis team in January 2015 as project manager, and is now in charge of all management and development of the company’s quality system.

Her strengths: rigorous, precise and honest!



Business Developer

After graduating from the Ecole des Bio-Industries de Cergy-Pontoise engineering school in 2012, Clarisse worked for several years in the cosmetics and dermatology industry, in particular in scientific promotion and communication, and in the relationship between marketing and the research laboratory. This enabled her to acquire skills in communication, scientific writing and partnership building. She joined Smaltis in August 2019 to take on the role of Business Developer, promoting the company’s activities and managing customer relations to meet their needs. Today, Clarisse manages all the company’s prospecting and communication activities.

Her strengths: flexible, good people skills and a positive attitude!


Alexandre TETARD

Project Manager

Alexandre completed a Master’s degree in Cellular and Molecular Signaling, which was accompanied by a 2-month internship in Nîmes with Unit 1047 in Bacterial Virulence and Infectious Diseases. In this context, he also completed a 6-month internship in Besançon with Unité Mixte de Recherche 6249 and, more specifically, in the bacteriology team, where he naturally continued his research as a PhD student in bacteriology, specializing in antibiotic resistance in hospital bacteria. Following these experiences, he joined the Smaltis team in November 2021.

His strengths: optimistic, strategic and curious!



Project Manager

Arnaud completed a Master 2 degree in Cellular and Molecular Physiopathology, which he complemented with professional experience as a studies and clinical research engineer at Besançon University Hospital and as a research assistant in genetic engineering at Oxford University. He then obtained his doctorate thanks to his work on the identification of new regulatory pathways involved in non-enzymatic resistance to aminoglycosides in Pseudomonas aeruginosa. After his thesis, he flourished as a teacher-researcher, before joining the Smaltis team in April 2022.

His strengths: thoughtful, calm and rational!




Laura obtained her Scientific Baccalaureate in Besançon, followed by a Biology Degree at the Faculty of Sciences in Besançon. She then joined the Smaltis team in June 2022 to support the various departments as Logistician, in order to organize the laboratory, help prepare manipulations, and manage relations and orders with our various suppliers. Today, Laura’s main mission is to ensure that all Smaltis employees have everything they need to carry out our customers’ projects.

Her strengths: reactive, organized and committed!



Managerial Missions Manager

Ana Sofia graduated from a business school in 2019 with a BTS in “Assistant Manager”. She then immersed herself in the world of work, accumulating 2 years of professional experience, before deciding to resume her academic career by successfully obtaining an undergraduate’s degree in “Communication and Webmarketing”. She is currently pursuing a Master’s degree in “Business Management”, on a sandwich course, to reinforce and deepen her business management skills. In this context, she joined Smaltis in October 2023 as a Managerial Missions Manager, to support the management of the company’s day-to-day business, in the areas of finance, administration, human resources, sales and communication.

Her strengths: versatile, committed and energetic!


Our values

Principles that guide our actions on a daily basis... our philosophy, our corporate culture.

Respect / Trust / Simplicity / Proximity / Curiosity

Read more

Join our team

Would you like to join the Smaltis adventure and its dynamic team? Would you like to get involved in exciting projects and take on new challenges with us? Are you motivated, curious and hard-working?
Please let us know what you’re looking for, what experience you’ve had, and what motivates you. Send us your application by filling in this form and uploading your CV and cover letter.
We will then contact you to discuss your application further!

    The laboratory

    Smaltis’ premises are located in France, in the heart of the TEMIS Santé zone in Besançon, and house all the laboratory’s activities, including offices and technical platforms. All services are carried out on site, within the microbiology, molecular biology and cell biology platforms.

    The laboratory

    Testimonials and references

    Delphine GALLAND
    Head of Preclinical Clinical Studies

    For the past 10 years, we have regularly turned to Smaltis for their services and expertise in microbiology, cellular biology, and molecular biology. The entrusted work focused on evaluating the efficacy and safety of various products related to infectious diseases. The smoothness of our interactions, the responsiveness of the entire team, and their adaptation to our regulatory requirements have allowed us to advance our research projects optimally. The trust we have placed in Smaltis over these 10 years has led us to include this provider among our preferred contacts.

    Thomas GLOUDEN
    PCR Development Expert

    As part of the development of a simple, rapid molecular test for the detection of certain pathogenic micro-organisms in milk, we needed to work with a company with expertise in microbiology. We were looking for a qualified and experienced laboratory to prepare calibrated microbial suspensions and purified genetic material from different bacterial species. By identifying Smaltis, we were able to fully achieve our objectives thanks to the expertise of their team. We now regularly rely on this trusted partner for our recurring needs.

    Nicolas COULIN
    Laboratory Manager

    Solicaz develops natural bacterial biostimulation solutions to meet the challenges of agro-ecological transition and climate change. These PGPG (Plant Growth Promoting Rhizobacteria) bacteria provide benefits for improving plant growth and resistance. In order to exploit their full potential, we needed to call on a molecular biology expert to robustly determine the identity of a pool of selected strains. We identified Smaltis, who fully met our expectations by providing comprehensive expertise. The laboratory proved to be a true partner of choice, with whom we worked jointly to identify and test the method best suited to our needs. Their flexibility and commitment ensure that we have reliable results, and despite the geographical distance that separates us, our various subsidiaries will continue to work with Smaltis.

    Laurence RINGENBACH
    Cell Biology Lab Manager,
    Immunodiagnostic Reagents,
    DIACLONE SAS part of Medixbiochemica

    Smaltis is a long-term partner with whom we have established a privileged relationship. We work in highly complementary domains and collaborate regularly to provide a comprehensive offering to our clients, utilizing microbiology and molecular biology services that we specifically require. We engage them for services such as sample contamination analysis, production of competent bacteria, and preparation of suspensions of inactivated strains for the development of new monoclonal antibodies. A true bond of trust has developed, facilitated by the geographical proximity of our respective locations and easy communication with their teams, whose flexibility, tenacity in problem-solving, and quality of work are crucial for us.

    Caroline GEBUS
    Bioprocess Scientist
    OM Pharma

    We use Escherichia coli strains to manufacture our Uro-Vaxom® product for the prevention of recurrent lower urinary tract infections and co-treatment of acute urinary tract infections and, in accordance with regulatory requirements, we must demonstrate the stability of our strains. We therefore asked SMALTIS to develop a tailor-made quality control method. In addition to their ability to listen to customer needs and propose new ideas, the SMALTIS team has also distinguished itself by the quality and accuracy of its analysis reports. At present, the partnership established with SMALTIS is a real asset for OM Pharma.

    Nicolas CHABERT
    Chief Technical Officer

    As part of the development of our microbial biostimulants, and to ensure the health and safety of users of our products, we needed to evaluate the cytotoxicity of bacterial strains against a cell line. In this context, we turned to Smaltis to meet our needs. Their attentiveness and rigor in setting up the experimental conditions to perfectly match the expectations of the project, as well as the regular exchanges we benefited from, totally satisfied us. The analyses carried out met our strictest expectations in terms of safety of use, and provided us with reliable, interpretable results.

    Eric SAMARUT
    Co-founder and Scientific Director

    Smaltis is an important partner for us, with whom we have established a close and early relationship to support the development of our new anti-infective molecules. We sought their recognized expertise in the field of antimicrobials and antibiotic resistance to support our proof of concept of the efficacy of our compounds, using specific strains from their mutant collection. With the help of growth kinetics, determination of Minimal Inhibitory Concentrations, and precise construction of mutant strains, along with their insightful advice and regular constructive exchanges, we obtained solid and essential elements to secure our data and continue our project.

    Pascal MERTENS
    R&D Director

    As part of the development of rapid in vitro diagnostic (IVD) tools for detecting infectious pathologies in humans, we needed to evaluate the performance of new tests dedicated to the detection of bacterial antibiotic resistance mechanisms. We approached Smaltis, a company specializing in microbiology and molecular biology, and found them ideally suited to our needs. Smaltis made its expertise available to assess the efficacy and robustness of our tests on clinical strains with very specific antibiotic resistance profiles, compared with a molecular biology method. The results confirmed the sensitivity, specificity and accuracy of our test, and enabled us to meet regulatory requirements. For us, the Smaltis laboratory is an expert player on whom we can rely to support our developments and obtain the data we need to bring our tools to market.

    Sophie MAC-MARY

    Smaltis is a laboratory that set up in the same building as our company, Skinexigence, from its inception. The proximity of our offices and the identification of a very interesting collaboration opportunity allowed us to quickly initiate a partnership to meet the growing demand from our clients for studies on the skin microbiota of volunteers. Specialized in the evaluation of the effectiveness of dermo-cosmetic products, it was only natural that we turned to Smaltis to provide our clients with expertise in the study of skin flora. For these studies, Smaltis performs skin sampling on our volunteers, sample preparation, and metagenomic analyses. The development of a very rigorous and calibrated protocol enables them to access relevant and reliable information regarding the evolution or not of the skin microbiota of a subject, in relation to the clinical parameters we observe.

    Olivier DHELLIN
    Director of Pharmaceutical Development

    During our program to develop and industrialize the production of our Kinoïdes® vaccines, SMALTIS has proven to be a partner of choice for optimizing one of our cytokine production systems. Its service consisted in optimizing the genetic heritage of the host bacterium by excising DNA from exogenous sequences. Very attentive and with a rare expertise in microbiology, the SMALTIS team has always been benevolent and has never hesitated to guide us by providing sound advice. It is with pleasure that we will again call upon the services of SMALTIS to help us in our next challenges.

    Agustina LLANOS
    Head of Biology

    We have collaborated with Smaltis on several occasions since 2014, notably as part of our ANT3273 project. This is an inhaled medicine targeting a key virulence factor of Pseudomonas aeruginosa involved in pathogenesis and would be an alternative or complement to existing antibiotic therapy for the treatment of P. aeruginosa infections in chronic respiratory diseases, such as bronchiectasis. Recently, Smaltis successfully completed a MLST sequencing project of a large number of strains with a very tight timeline to study the clonality of clinical isolates of P. aeruginosa from cystic fibrosis patients. The Smaltis team stands out for its expertise, proactive approach, and its communication and adaptability, which is why we continue to trust them.

    Karine ROGET
    Chief Scientific Officer

    As part of our programs to harness microbiota to improve human health, we called on Smaltis to demonstrate the antimicrobial activity of our pharmaceutical product to combat vaginosis. Smaltis demonstrated great expertise and efficiency in setting up relevant protocols adapted to our objective, while coping with the complexities inherent in handling particular strains in equally complex environments. The energy deployed by the Smaltis team and their ability to adapt have confirmed our choice of this expert, on whom we can rely for our other projects.

    Maxime GUALTIERI

    As part of our anti-infective molecule developments, we have repeatedly sought the expertise of the Smaltis team for cloning and construction of specific mutants. The services provided by Smaltis have notably contributed to our study describing and characterizing new mechanisms of resistance to Odilorhabdines in Klebsiella pneumoniae, which was published in 2021. We know that we can rely on their know-how and expert scientific advice for our future developments.

    Romain DAILLERE
    Head of Preclinical Research - Co-founder

    As part of the Oncobax®-AK project and the development of Live Biotherapeutic Products to potentiate the efficacy of cancer immunotherapies, we called upon Smaltis' services to characterize one of our candidate bacterial strains. The objective was to provide a complete file to the regulatory authorities regarding the characteristics of the strain, before initiating clinical studies. The Smaltis team worked hard to develop the protocols and test conditions necessary to determine the specificities of the strain of interest. The rigor shown by Smaltis' researchers, the quality and detail of the data transmitted, as well as the scientific relevance of the various characterization tests, allowed us to meet the regulatory requirements and to initiate the clinical trials with confidence. We are delighted to have collaborated with Smaltis.

    Eric ROBINET
    Founder and President

    Specialized in the production of cell banks from blood, for research and patient use, we needed to rely on a microbiology company to ensure the absence of contamination in our products from the start of our preparations. Established at the time in the premises of the EFS, it was only natural that we turned to Smaltis, located a few steps from our laboratories. Their work approach and the reliability of their results were exactly what we were looking for, and for several years now, we have entrusted them with all our microbiological analyses. The growth of our respective companies led us to look for new premises... and it is with pleasure that we took over the premises of Smaltis, who then moved into the building just across the street! It is important to have Smaltis in our network of reliable partners with common values, to contribute to the improvement of health!

    Nathalie ROUDIER
    Science & Innovation Director

    In the context of the use of probiotic strains as dietary supplements, we needed to evaluate the inhibition potential of pathogenic strains. We identified Smaltis, with whom we were able to discuss the various possible models adapted to our needs. Smaltis was able to deploy and optimize a protocol to demonstrate the desired effects. The Smaltis team proved to be very attentive to our needs and was able to meet the challenges we faced in adapting to the constraints of the living world. We were also able to call on the company to determine the Minimum Inhibitory Concentration of probiotic strains, in line with EFSA recommendations. We will continue to call on the Smaltis team if we ever need to turn to a quality service provider specialized in microbiology and molecular biology.

    Jérôme SCHMEISSER and Christelle IACONIS
    Biology lab manager
    and Scientist

    In the context of our developments in animal health dietary supplements, we turned to SMALTIS to assess the impact of our products on the expression of genes of interest in different tissues. The molecular biology expertise of SMALTIS allows us to rely on this laboratory, whose qualitative results provide us with robust and reliable data. We also benefit from constructive exchanges with their teams to progress together throughout the project. SMALTIS thus constitutes a true extension of our R&D department, allowing us to focus on our own expertise while relying on this partner with whom we will continue to collaborate.

    Elise JACQUIN
    Associate Professor in Cell Biology
    Unité CTM, Inserm U1231, Université de Bourgogne

    To test the impact of mutations identified in cancer patients, we needed to reproduce them in an expression plasmid in order to measure their effects in cell transfection models. So we turned to Smaltis and their expertise in genetic engineering. The team understood our needs perfectly, and was able to efficiently implement the directed mutagenesis strategy to obtain the desired plasmids, while guaranteeing their high quality. As a result, we were able to rapidly carry out test manipulations, which proved conclusive and enabled us to obtain the preliminary data needed to submit a major funding application. We were fully satisfied with the team's professionalism in managing this project, and with the regular and easy exchanges of information on the progress of the manipulations. We look forward to working with Smaltis again in the future.

    Pierre BELICHARD

    As part of the development of our candidate EB8018 designed to block bacteria expressing virulence factor FimH (a key inducer of the inflammatory cascade of the intestine, particularly in patients with Crohn disease), we have successively called upon the services of SMALTIS. In the preclinical phase, they first quantified in vitro the adhesion and invasion capacities of a collection of strains isolated from patients on a model of intestinal cell infection and then evaluated the impact of our molecule on these strains. The quality of the work performed, the level of expertise of the team combined with the ability to listen and adapt, led us to include SMALTIS as a service provider in our Phase 1b clinical study. The team developed a customized procedure to isolate and dissociate bacteria called "adherent" and "invasive" in intestinal biopsies, and then demonstrated the action of our EB8018 compound on these strains. SMALTIS continues to support the development of EB8018 in a phase 2a clinical trial.

    Igor MIERAU
    Director of Genetic Engineering and Manufacturing

    Aurealis Therapeutics develops multi-target, scalable low COGS cell & gene therapies for unmet medical needs. As part of this effort, we needed to identify a laboratory to support specific research studies and meet regulatory objectives. We identified Smaltis, CRO expert in microbiology and molecular biology, able to answer our needs such as assessing the antimicrobial properties of some of our bacterial strains. We also exchanged about other protocols that could be put in place for our projects of strain characterization or clinical samples analysis. Smaltis is really a true partner for us, with which we can exchange about different purposes and collaborate to identify the best tests to be developed. We are happy to work with this passioned, reactive and flexible team!

    Clara LEANDRO
    Head of Infection

    The advancement of Technophage's therapeutic pipeline products has received crucial support from SMALTIS in the scope of genetic modification of bacterial strains. Throughout this collaborative effort, the SMALTIS scientific team has demonstrated remarkable commitment to resolving various technical challenges, successfully aligning with our objective of acquiring a set of strains for our internal utilization, all within the stipulated timeline.

    News and articles

    ECCMID – ESCMID Global

    Smaltis attends the 34th edition of the ECCMID international congress, renamed ESCMID Global, in Barcelona from April 27 to 30, 2024. This clinical microbiology and infectious diseases event is one of the largest and most important congresses in the field of infection, bringing together over 16,000 participants from all over the world to contribute to the dissemination of scientific knowledge.


    Sanofi Vaccines R&D Day

    Smaltis attends the Sanofi Vaccines R&D Day, organized by Sanofi in partnership with Lyonbiopôle, Enosis Santé and Polepharma!
    This event aims to foster partnerships around 5 themes: antimicrobial approaches, therapeutic vaccines and antibodies, mucosal or skin delivery of vaccines, immunology, and antigen design. Quite a program!

    Cédric Muller will be present at this event, which will take place on April 11, 2024, at 14 Espace Henry Vallée in Lyon.


    Viruses at the service of humanity?

    Once upon a time, the English bacteriologist Ernest Hankin demonstrated for the first time the presence of anti-bacterial entities in the waters of Indian rivers, putting humanity on the path to a promising anti-infectious therapy that is more relevant than ever.


    Microbiota & Health Day 7th edition

    Smaltis is delighted to be taking part in the 7th edition of Microbiota & Health Day, organized by Lyonbiopôle and Alliance Promotion Microbiote, on March 26, 2024 in Lyon. The aim of this day is to bring together academic, clinical and industrial players to discuss topical issues that are driving innovation in the field of microbiota and their impact on health.


    AMR Conference 8th edition

    Smaltis is happy to participate to the 8th edition of AMR Conference in Basel from March 6th to 7th 2024, a platform for SMEs, start-ups, big pharma, academia, investors and public institutions to discuss strategies and specific challenges faced by the innovation ecosystem in bringing new antimicrobial treatments and diagnostics to the market.


    The same… But better!

    The year 2024 marks the 10th anniversary (already!) of the Smaltis adventure! 10 years of microbiology, 10 years of molecular biology, 10 years of passion, 10 years of twists and turns, 10 years of growth, 10 years of self-reflection, 10 years of continuous improvement, 10 years of scientific spirit, 10 years of ambition, 10 years of collaboration, 10 years of human relationships…

    It was necessary to celebrate this milestone, and not just by blowing out the candles.


    The Polepharma Microbiomics Days

    Smaltis is delighted to have participated in and sponsored, for the fourth consecutive year, the Polepharma Microbiomics Days, held in Rouen on November 22 and 23, 2023.


    The man who wanted to extend lifespan

    Once upon a time, more than a century ago, Elie Metchnikoff hypothesized that health could be improved, and senility delayed by modulating the intestinal microbes thanks to bacteria present in yogurt. This zoologist and microbiologist was thus one of the first scientists to take an interest in gut microbiota and what we now call probiotics, the consumption of which he claimed helped to fight against aging.

    This is the story of “the man who wanted to extend lifespan”.


    All our sincere wishes

    In this new year that begins, let’s take the time…

    Let’s take the time to extend our best wishes to you, from the bottom of our hearts. It seems essential to us, during these periods conducive to gratitude, to prioritize human relationships as the most important aspect of our lives.