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Pharma & Animal health

Our expertise in microbiology and molecular biology enables us to support the development of your candidates that contribute to the health of domestic animals or livestock through preventive or curative approaches. To ensure that your projects are carried out under the best possible conditions, our team will support you throughout your development, from the research phases to the monitoring of animal studies.

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Your needs

In the context of the development of your drug candidates aimed at improving animal health, you are seeking an in vitro services provider in microbiology and molecular biology to support your projects in the design and enhancement of products at all stages. Smaltis is the ideal company to meet your needs, offering high scientific expertise and a customized approach.

Your products

  • Antibiotics
  • Antifungals
  • Antimicrobial peptides
  • Antibacterial antibodies
  • Vaccine components
  • Other molecules for anti-infectious purposes
  • Other compounds acting on animal health through the microbiome
  • Disinfectant products

The approaches you work on

Are you working on the anti-infectious axis, on modulating a microbiome, or on developing compounds used for animal vaccination? Whatever strategy you employ to bring benefits to animal health, the Smaltis team, along with its expertise, knowledge, and technologies, is at your disposal to facilitate and successfully execute your projects.

Our offer

At what stage are you?

DEVELOPMENT STAGES 1

RESEARCH & SELECTION

2

PROOF OF CONCEPT/EFFICACY

3

BIOPROCESSES

4

ANIMAL STUDIES

OUR SERVICES

Screening of candidates,
Characterization of products in terms of functionality and safety

Understanding of action mechanisms,
Biomarker research

Development and optimization of bioprocesses,
Supply and optimization of strain-producing compounds

Support for animal studies through in vitro monitoring of samples,
Assistance in data analysis

Why choose Smaltis?

Our services and support enable you to supply, enhance, and secure your data within a rigorous scientific framework. We have been working for several years on various projects in animal health, and our teams of scientists are capable of discussing your objectives and recommending the most suitable and relevant manipulations for your needs. You can rely on Smaltis for complete project management, adaptation to your requirements, and guaranteed traceability of the experiments conducted.

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They trust us

Testimonials and references

Hervé MARION, DVM
General Secretary
CEESA

As part of our European activities in the field of animal health, we entrusted Smaltis with the handling and storage of our biological samples. Their facilities provide reliable and fully controlled storage conditions, well suited to the nature and strategic value of these resources. Beyond storage, the quality of the exchanges and the follow-up provided by the Smaltis team is a real asset. Communication is smooth, information is clear, and traceability is rigorous, which greatly facilitates the long-term management of our collections. The ability to process or analyse the strains directly at Smaltis when needed further strengthens the value of this partnership. This flexibility allows us to anticipate scientific or regulatory needs while relying on a single, reliable, responsive partner with strong microbiological expertise.

Delphine GALLAND
Head of Preclinical Clinical Studies
VETOQUINOL

For the past 10 years, we have regularly turned to Smaltis for their services and expertise in microbiology, cellular biology, and molecular biology. The entrusted work focused on evaluating the efficacy and safety of various products related to infectious diseases. The smoothness of our interactions, the responsiveness of the entire team, and their adaptation to our regulatory requirements have allowed us to advance our research projects optimally. The trust we have placed in Smaltis over these 10 years has led us to include this provider among our preferred contacts.

Jérôme SCHMEISSER
Biology Lab Manager
DSM-FIRMENICH

In the context of our developments in animal health dietary supplements, we turned to SMALTIS to assess the impact of our products on the expression of genes of interest in different tissues. The molecular biology expertise of SMALTIS allows us to rely on this laboratory, whose qualitative results provide us with robust and reliable data. We also benefit from constructive exchanges with their teams to progress together throughout the project. SMALTIS thus constitutes a true extension of our R&D department, allowing us to focus on our own expertise while relying on this partner with whom we will continue to collaborate.

Stéphane KROEMER
Preclinical and Clinical trials officer
DÔMES PHARMA

In the context of our animal health activities, we needed a partner capable of retrieving, centralizing, and securing our own strain collections as well as those provided by European collaborators. Smaltis quickly addressed this need by implementing a comprehensive and reliable storage solution. Their ability to manage different types of collections streamlines our logistics and ensures the rigorous traceability we rely on. Beyond storage, being able to draw on their expertise for strain identification and characterization enables us to confidently anticipate the next steps of our projects. This collaboration strengthens our operational efficiency while safeguarding strategic biological resources for our programs. We know our strains are managed with a high level of scientific rigor and a truly valuable sense of service.

Pierre BELICHARD
CEO
ENTEROME

As part of the development of our candidate EB8018 designed to block bacteria expressing virulence factor FimH (a key inducer of the inflammatory cascade of the intestine, particularly in patients with Crohn disease), we have successively called upon the services of SMALTIS. In the preclinical phase, they first quantified in vitro the adhesion and invasion capacities of a collection of strains isolated from patients on a model of intestinal cell infection and then evaluated the impact of our molecule on these strains. The quality of the work performed, the level of expertise of the team combined with the ability to listen and adapt, led us to include SMALTIS as a service provider in our Phase 1b clinical study. The team developed a customized procedure to isolate and dissociate bacteria called "adherent" and "invasive" in intestinal biopsies, and then demonstrated the action of our EB8018 compound on these strains. SMALTIS continues to support the development of EB8018 in a phase 2a clinical trial.

Romain DAILLERE
Head of Preclinical Research - Co-founder
EVERIMMUNE

As part of the Oncobax®-AK project and the development of Live Biotherapeutic Products to potentiate the efficacy of cancer immunotherapies, we called upon Smaltis' services to characterize one of our candidate bacterial strains. The objective was to provide a complete file to the regulatory authorities regarding the characteristics of the strain, before initiating clinical studies. The Smaltis team worked hard to develop the protocols and test conditions necessary to determine the specificities of the strain of interest. The rigor shown by Smaltis' researchers, the quality and detail of the data transmitted, as well as the scientific relevance of the various characterization tests, allowed us to meet the regulatory requirements and to initiate the clinical trials with confidence. We are delighted to have collaborated with Smaltis.

News and articles

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The skin microbiome is not mere scenery. It is a functional component of the skin, involved in protection against pathogens, immune dialogue, and the modulation of inflammation. It is a dynamic ecosystem shaped by subtle interactions between bacteria, yeasts, the host, and the environment.

Our approach is grounded in a simple conviction: understanding a microbiome is not merely about identifying it. It is about knowing how to culture it, interrogate it, and generate scientifically defensible data.

This is precisely how we approach the skin microbiome: as a complex ecosystem whose actors, dynamics, and mechanisms must be mastered before attempting to modulate its balance.

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The Story of a Microbiota That Became a Medicine

Once upon a time, in the hospitals of the twenty-first century, there was an infection that even antibiotics could no longer silence. An opportunistic infection caused by a bacterium called Clostridioides difficile, it often appeared in patients who were already vulnerable… and, above all, already heavily treated. Let us look back at the history of this infection, which gave rise to new therapeutic approaches.

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Probiotic Characterization: Demonstrating Safety and Substantiating Activity

Probiotics are often presented as a simple category. In reality, their characterization has become a demanding scientific and regulatory exercise. It is no longer enough to identify a species or to invoke a favorable history of use: the demonstration must now be conducted at the strain level, in a way that is consistent with the intended use, the target population, and the applicable regulatory framework. In the main reference frameworks, a microorganism can be qualified as a probiotic in the strict sense only if it is sufficiently characterized, safe for its intended use, alive at a relevant dose until the end of the product’s shelf life, and associated with a documented health benefit. [1,5,7,8]

The key question therefore becomes: what can we robustly demonstrate about its identity, safety, and functional activity? This is particularly true for new or poorly documented strains, for which taxonomy alone is not sufficient. The EFSA, GRAS, and Canadian frameworks converge on one central point: useful characterization is strain-level characterization interpreted in light of the final use. [1-6]

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Designing Bacterial Mutants: From Gene Editing to Robust Strain Engineering

The construction of bacterial mutants is a cornerstone of microbiology. Historically used to decipher gene function, it now plays an equally strategic role in bioproduction, biotechnology, and the development of therapeutic bacteria, where the engineered strain itself may ultimately become the final product.

This shift has profoundly changed how mutagenesis projects are approached. Today, the objective is no longer simply to modify a gene, but to design a strain aligned with its final application, operational constraints, and regulatory expectations.

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Lugdunin: the secret weapon of an indomitable bacterium

Once upon a time, an invisible battle was raging deep inside our noses. A microscopic battlefield, where bacteria fought relentlessly to defend their territory. Picture a small village of indomitable Gauls, surrounded on all sides… but instead of Romans, it’s microbes. And in this surprisingly strategic setting, a most unexpected antibiotic was discovered: lugdunin.

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2026: Taking on New Scientific Challenges Together

As we step into 2026, the entire Smaltis team sends you our warmest wishes. May this new year bring clarity, creativity, meaningful collaborations — and a few scientific breakthroughs that get the attention they deserve.

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Antimicrobial activity testing: measuring, understanding, and anticipating resistance

Every day, antimicrobials face their natural adversaries: bacteria.
But in this silent war, nothing remains static — bacteria learn, adapt, defend themselves… and develop increasingly sophisticated resistance mechanisms.
Smaltis is a microbiology CRO specialized in the study of antimicrobial resistance and the preclinical development of antimicrobials.
We support the developers of new antibiotics, peptides, biocides, and other anti-infective agents with a comprehensive panel of in vitro assays designed to meet the most demanding R&D challenges.

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Meeting the Innovation

Smaltis at the Key Industry Events of Autumn 2025! From medical devices to biotherapies, from fundamental research to industrial production, we meet project leaders to better understand microbiology needs and build new collaborations.

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New Offer Structure: 2 Business Units Supporting Your Projects

At Smaltis, our ambition remains unchanged: bringing microbiological excellence to your innovations.
To better address the diversity of your needs, we have structured our offer around 2 complementary Business Units, true pillars of our scientific and technical commitment.

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Malassezia: Cultivating the Invisible – A Challenge Met

Some yeasts are particularly resistant… especially Malassezia restricta.

This lipophilic yeast, naturally present on human skin, is involved in various imbalances of the skin microbiota, notably those linked to dandruff or seborrheic dermatitis. But cultivating it in the laboratory is no easy task!

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