Some yeasts are particularly resistant… especially Malassezia restricta.
This lipophilic yeast, naturally present on human skin, is involved in various imbalances of the skin microbiota, notably those linked to dandruff or seborrheic dermatitis. But cultivating it in the laboratory is no easy task!
Given the complexity of this yeast—well-known for being difficult to isolate and grow in vitro—our team has leveraged its full microbiological expertise to develop a dedicated and controlled culture protocol, tailored to the specific metabolic requirements of Malassezia restricta. Lipid enrichment, precise incubation conditions, controlled growth kinetics—every parameter has been optimized to ensure a stable, reproducible, and exploitable culture for R&D applications.
Today, Smaltis is able to cultivate Malassezia restricta strains to support innovative projects aimed at developing new active ingredients or anti-dandruff formulations. This advancement paves the way for studies on microbial models representative of the scalp and allows for a deeper understanding of interactions between yeasts and dermatologically relevant compounds.
Is your project focused on the skin microbiota? Need a Malassezia model for your evaluations?
Our experts are here to co-develop your study and adapt our models to meet your specific objectives.
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Malassezia: Cultivating the Invisible – A Challenge Met
Some yeasts are particularly resistant… especially Malassezia restricta.
This lipophilic yeast, naturally present on human skin, is involved in various imbalances of the skin microbiota, notably those linked to dandruff or seborrheic dermatitis. But cultivating it in the laboratory is no easy task!
Once upon a time was cheese, a high place of communication between fungi and bacteria.
Attracted by the smell of French cheeses, a team from Tufts University published work on how, in Camembert, Roquefort and other festivities, bacteria use compounds produced by fungi and adapt their behavior.
Once upon a time, the English bacteriologist Ernest Hankin demonstrated for the first time the presence of anti-bacterial entities in the waters of Indian rivers, putting humanity on the path to a promising anti-infectious therapy that is more relevant than ever.
Smaltis attends the 34th edition of the ECCMID international congress, renamed ESCMID Global, in Barcelona from April 27 to 30, 2024. This clinical microbiology and infectious diseases event is one of the largest and most important congresses in the field of infection, bringing together over 16,000 participants from all over the world to contribute to the dissemination of scientific knowledge.
Smaltis attends the Sanofi Vaccines R&D Day, organized by Sanofi in partnership with Lyonbiopôle, Enosis Santé and Polepharma!
This event aims to foster partnerships around 5 themes: antimicrobial approaches, therapeutic vaccines and antibodies, mucosal or skin delivery of vaccines, immunology, and antigen design. Quite a program!
Cédric Muller will be present at this event, which will take place on April 11, 2024, at 14 Espace Henry Vallée in Lyon.
Smaltis is delighted to be taking part in the 7th edition of Microbiota & Health Day, organized by Lyonbiopôle and Alliance Promotion Microbiote, on March 26, 2024 in Lyon. The aim of this day is to bring together academic, clinical and industrial players to discuss topical issues that are driving innovation in the field of microbiota and their impact on health.
Smaltis is happy to participate to the 8th edition of AMR Conference in Basel from March 6th to 7th 2024, a platform for SMEs, start-ups, big pharma, academia, investors and public institutions to discuss strategies and specific challenges faced by the innovation ecosystem in bringing new antimicrobial treatments and diagnostics to the market.
The year 2024 marks the 10th anniversary (already!) of the Smaltis adventure! 10 years of microbiology, 10 years of molecular biology, 10 years of passion, 10 years of twists and turns, 10 years of growth, 10 years of self-reflection, 10 years of continuous improvement, 10 years of scientific spirit, 10 years of ambition, 10 years of collaboration, 10 years of human relationships…
It was necessary to celebrate this milestone, and not just by blowing out the candles.
Smaltis is delighted to have participated in and sponsored, for the fourth consecutive year, the Polepharma Microbiomics Days, held in Rouen on November 22 and 23, 2023.
Once upon a time, more than a century ago, Elie Metchnikoff hypothesized that health could be improved, and senility delayed by modulating the intestinal microbes thanks to bacteria present in yogurt. This zoologist and microbiologist was thus one of the first scientists to take an interest in gut microbiota and what we now call probiotics, the consumption of which he claimed helped to fight against aging.
This is the story of “the man who wanted to extend lifespan”.
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