Back to homepage Our expertise: Antimicrobials

Develop, test, and monitor your antimicrobials – from preclinical research to clinical programs and epidemiological surveillance.

With more than 15 years of academic research in antimicrobial resistance, Smaltis supports the development of your anti-infective products: antibiotics, antifungals, antimicrobial peptides, bacteriophages, strains with antimicrobial properties, vaccines/antibodies, hygiene and disinfection products, and any other antimicrobial compound.
Through our two business units – Research Microbiology and Precision Microbiology – we secure every stage, from in vitro screening to clinical validation.

Our offer

Comprehensive and precise solutions to support your anti-infective programs from research phases to epidemiosurveillance studies

DEVELOPMENT STEPS 1

Preclinical Research & Selection

2

Resistance Risk Evaluation

3

Clinical Studies & Epidemiological Surveillance

YOUR NEEDS

• Candidate screening and selection
• Efficacy validation
• Cytotoxicity evaluation

• Anticipation of resistance emergence
• Identification of known or novel resistance mechanisms

• Central Lab services
• Efficacy studies on clinical samples
• Monitoring of antimicrobial resistance

OUR SOLUTIONS

→ Standard or customized MIC, MBC, time-kill assays, FIC Index (checkerboard assay)
→ Cytotoxicity tests

→ Serial passages
→ Mutant frequency analysis
→ Mechanism identification

→ Centralization, research & identification of isolates
→ Resistance level assessment

Our Promise: Expertise and know‑how to secure your developments

They trust us

Testimonials and references

Agustina LLANOS
Head of Biology
ANTABIO

We have collaborated with Smaltis on several occasions since 2014, notably as part of our ANT3273 project. This is an inhaled medicine targeting a key virulence factor of Pseudomonas aeruginosa involved in pathogenesis and would be an alternative or complement to existing antibiotic therapy for the treatment of P. aeruginosa infections in chronic respiratory diseases, such as bronchiectasis. Recently, Smaltis successfully completed a MLST sequencing project of a large number of strains with a very tight timeline to study the clonality of clinical isolates of P. aeruginosa from cystic fibrosis patients. The Smaltis team stands out for its expertise, proactive approach, and its communication and adaptability, which is why we continue to trust them.

Clara LEANDRO
Head of Infection
TECHNOPHAGE

The advancement of Technophage's therapeutic pipeline products has received crucial support from SMALTIS in the scope of genetic modification of bacterial strains. Throughout this collaborative effort, the SMALTIS scientific team has demonstrated remarkable commitment to resolving various technical challenges, successfully aligning with our objective of acquiring a set of strains for our internal utilization, all within the stipulated timeline.

Maxime GUALTIERI
CSO
NOSOPHARM

As part of our anti-infective molecule developments, we have repeatedly sought the expertise of the Smaltis team for cloning and construction of specific mutants. The services provided by Smaltis have notably contributed to our study describing and characterizing new mechanisms of resistance to Odilorhabdines in Klebsiella pneumoniae, which was published in 2021. We know that we can rely on their know-how and expert scientific advice for our future developments.

Olivier DHELLIN
Director of Pharmaceutical Development
NEOVACS

During our program to develop and industrialize the production of our Kinoïdes® vaccines, SMALTIS has proven to be a partner of choice for optimizing one of our cytokine production systems. Its service consisted in optimizing the genetic heritage of the host bacterium by excising DNA from exogenous sequences. Very attentive and with a rare expertise in microbiology, the SMALTIS team has always been benevolent and has never hesitated to guide us by providing sound advice. It is with pleasure that we will again call upon the services of SMALTIS to help us in our next challenges.

Delphine GALLAND
Head of Preclinical Clinical Studies
VETOQUINOL

For the past 10 years, we have regularly turned to Smaltis for their services and expertise in microbiology, cellular biology, and molecular biology. The entrusted work focused on evaluating the efficacy and safety of various products related to infectious diseases. The smoothness of our interactions, the responsiveness of the entire team, and their adaptation to our regulatory requirements have allowed us to advance our research projects optimally. The trust we have placed in Smaltis over these 10 years has led us to include this provider among our preferred contacts.

Eric SAMARUT
Co-founder and Scientific Director
OSTA THERAPEUTICS

Smaltis is an important partner for us, with whom we have established a close and early relationship to support the development of our new anti-infective molecules. We sought their recognized expertise in the field of antimicrobials and antibiotic resistance to support our proof of concept of the efficacy of our compounds, using specific strains from their mutant collection. With the help of growth kinetics, determination of Minimal Inhibitory Concentrations, and precise construction of mutant strains, along with their insightful advice and regular constructive exchanges, we obtained solid and essential elements to secure our data and continue our project.

News and articles

New Offer Structure: 2 Business Units Supporting Your Projects

At Smaltis, our ambition remains unchanged: bringing microbiological excellence to your innovations.
To better address the diversity of your needs, we have structured our offer around 2 complementary Business Units, true pillars of our scientific and technical commitment.

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Malassezia: Cultivating the Invisible – A Challenge Met

Some yeasts are particularly resistant… especially Malassezia restricta.

This lipophilic yeast, naturally present on human skin, is involved in various imbalances of the skin microbiota, notably those linked to dandruff or seborrheic dermatitis. But cultivating it in the laboratory is no easy task!

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Talk and Cheese

Once upon a time was cheese, a high place of communication between fungi and bacteria.

Attracted by the smell of French cheeses, a team from Tufts University published work on how, in Camembert, Roquefort and other festivities, bacteria use compounds produced by fungi and adapt their behavior.

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Viruses at the service of humanity?

Once upon a time, the English bacteriologist Ernest Hankin demonstrated for the first time the presence of anti-bacterial entities in the waters of Indian rivers, putting humanity on the path to a promising anti-infectious therapy that is more relevant than ever.

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ECCMID – ESCMID Global

Smaltis attends the 34th edition of the ECCMID international congress, renamed ESCMID Global, in Barcelona from April 27 to 30, 2024. This clinical microbiology and infectious diseases event is one of the largest and most important congresses in the field of infection, bringing together over 16,000 participants from all over the world to contribute to the dissemination of scientific knowledge.

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Sanofi Vaccines R&D Day

Smaltis attends the Sanofi Vaccines R&D Day, organized by Sanofi in partnership with Lyonbiopôle, Enosis Santé and Polepharma!
This event aims to foster partnerships around 5 themes: antimicrobial approaches, therapeutic vaccines and antibodies, mucosal or skin delivery of vaccines, immunology, and antigen design. Quite a program!

Cédric Muller will be present at this event, which will take place on April 11, 2024, at 14 Espace Henry Vallée in Lyon.

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Microbiota & Health Day 7th edition

Smaltis is delighted to be taking part in the 7th edition of Microbiota & Health Day, organized by Lyonbiopôle and Alliance Promotion Microbiote, on March 26, 2024 in Lyon. The aim of this day is to bring together academic, clinical and industrial players to discuss topical issues that are driving innovation in the field of microbiota and their impact on health.

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AMR Conference 8th edition

Smaltis is happy to participate to the 8th edition of AMR Conference in Basel from March 6th to 7th 2024, a platform for SMEs, start-ups, big pharma, academia, investors and public institutions to discuss strategies and specific challenges faced by the innovation ecosystem in bringing new antimicrobial treatments and diagnostics to the market.

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The same… But better!

The year 2024 marks the 10th anniversary (already!) of the Smaltis adventure! 10 years of microbiology, 10 years of molecular biology, 10 years of passion, 10 years of twists and turns, 10 years of growth, 10 years of self-reflection, 10 years of continuous improvement, 10 years of scientific spirit, 10 years of ambition, 10 years of collaboration, 10 years of human relationships…

It was necessary to celebrate this milestone, and not just by blowing out the candles.

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The Polepharma Microbiomics Days

Smaltis is delighted to have participated in and sponsored, for the fourth consecutive year, the Polepharma Microbiomics Days, held in Rouen on November 22 and 23, 2023.

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