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Our offer: Strain collections
Large strain collections available for your projects!
Are you looking for specific strains? Smaltis and its network of partners will do everything to find them for you!
Indeed, Smaltis offers you the provision of bacterial or fungal strains from various collections, with the aim of allowing you to use microbial resources specifically tailored to your needs. These strains can be used directly in the manipulations we implement for your projects, or, in some cases, they can be transmitted to you so that you can carry out your experiments successfully.
Patient-Derived Strains
Through its exclusive collaboration with the Biologic Resource Center – Filière Microbiologique de Besançon (CRB-FMB) at the Jean Minjoz University Hospital, Smaltis provides access to over 80,000 strains isolated from hospitalized patients suffering from various pathologies. These clinical isolates are cataloged based on geography, year of isolation, antibiotic resistance phenotype, sample source, and patient demographic data. Each strain is accompanied by the date and sampling conditions, patient’s clinical status and whether antibiotic therapy was prescribed or not.
Reference Strains
Furthermore, Smaltis offers the opportunity to conduct work on reference strains sourced from various bioresources such as ATCC, DSMZ, BCCM COLLECTIONS, Westerdijk Fungal Biodiversity Institute, Institut Pasteur (CIP), and more. Among the species we already possess are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli, and various Enterobacter species.
Genetically Modified Bacterial Strains
Through its expertise in molecular biology, Smaltis has established collections of genetically modified bacterial strains that can be used in your projects. These strains are characterized both phenotypically and genotypically.
Strains for Early Antibiotic resistance Study
Since its establishment, Smaltis has been building proprietary mutant banks specific to different species such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae. These mutants exhibit different antibiotic resistance profiles and are characterized within well-controlled genetic backgrounds. Among the targeted resistance mechanisms are active efflux, enzyme production, and antibiotic target mutations. These mutant banks, designed specifically for the early study of the role and nature of resistance mechanisms commonly found in clinical settings, allow for anticipating the adaptation of microorganisms to future antimicrobial molecules.
Strains for Bioproduction
In addition to the study of antibiotic resistance, Smaltis also invests in the development of tools for bioproduction. Consequently, Smaltis owns a strain of Escherichia coli BL21 with deleted genes encoding for phage DE3, constructed on animal-free media.
Smaltis also possesses a chassis derived from the reference strain of Pseudomonas aeruginosa PAO1, which is hypersensitive to antibiotics and hypovirulent. Additionally, finely controlled and inducible expression plasmids are available. These tools are accessible through licensing for commercial activities.
If your desired strain is not available in the catalog, we can tailor-build it for you! (see our Bioproduction offer)
Support Service: Strain and Product Storage
Additionally, Smaltis offers dedicated storage space specifically designed for microorganisms and pharmaceutical products, available for an unlimited duration. This storage is maintained at a controlled temperature of -80°C, with a continuous alarm system.
This storage solution enables you to have a secure backup of your bacterial or fungal strains or to store pharmaceutical products until they are needed. A storage certificate is regularly provided, including details related to the preservation, and is updated with each modification.
This service ensures the longevity and safety of your valuable microbial resources and pharmaceutical products, allowing you to access them whenever necessary, supported by a comprehensive documentation and monitoring system.
